多数人对Neuralink这个名字并不熟悉,但这家初创公司其实也是埃隆·马斯克创立的。Neuralink的主要开发技术在于“脑机接口”,通俗而言就是将人脑与电脑连接起来进行交互。马斯克曾在推特和播客上分享过很多畅想,宣称这一技术可以缓解抑郁症、治疗强迫性神经障碍、创伤性脑损伤等等,但Neuralink一直都很神秘,鲜少出现在公众的视线当中。
正因如此,这两天出现了一个重磅消息:马斯克宣布要在当地时间8月28日下午三点(北京时间8月29日清晨6点)现场直播Neuralink脑机接口技术的“进展情况”。
马斯克在一年前曾向外界透露过Neuralink的冰山一角。2019年,Neuralink团队展示了一些搭载在细小探针上的微型电极,指出这些电极可以在损伤最小化的基础上穿透大脑组织,帮助创伤性脑损伤患者恢复大脑功能,并表示该项研究已在鼠类及灵长类动物身上完成了试验。
那么Neuralink现在的研究进展到底到了哪一步,又是否会实现马斯克的预言呢?以下是笔者就近期所有信息梳理的详细概要。
(Neuralink在)不久后就能将其技术植入人体
5月7日,马斯克在播客上作客人气节目《Joe Rogan Experience》时预测,“Neuralink在一年内就能将神经链接植入到人体内部。”不过这种植入技术并不新鲜,目前的临床医学已经可以在治疗癫痫和帕金森这类疾病的时候运用这种方法了,只是风险较高,有可能会使患者大脑出血而亡。
美国国防高级研究计划署生物技术办公室前负责人贾斯汀·桑切斯估计,全球大约有20万人的大脑中携带着某种被植入的神经技术。事实上,这种技术已经相当完备,以至于美国巴特尔纪念研究所甚至开发了一种可以帮助球手提升“挥杆速度”的神经技术设备。
另外,马斯克在当期节目中还透露,“Neuralink会在2020年进入人体实验阶段。”进行人体实验也就意味着Neuralink需要获得美国食品和药物管理局的豁免,使其免于连续性的常规监管范畴之内。这种可能性并不大,但也不是并非完全没有可能,因为大脑植入物获得豁免的情况还是存有很多先例的,只是Neuralink可能要面临更多额外的质疑和挑战。
据美国健康新闻网本周一的报道,Neuralink公司内部的关系并不和谐,该报道援引Neuralink前员工的说法,称“公司的企业文化很混乱,人才流动很快。”
(Neuralink可以)有效治疗上瘾和抑郁症状
6月10日,一位推特用户向马斯克提问,“Neuralink的技术是否可以用来抑制大脑中的上瘾症状和抑郁症状。”对此,马斯克的回答是:“当然,这项技术即伟大又可怕。”
“在大脑中放置电极可以有效缓解上瘾和抑郁。”这一点一直都是所有神经科学家所公认的。除了Neuralink,还有很多研究者也在研究这一领域,其中就包括明尼苏达大学的精神病学家和生物医学工程师埃里卡·维奇教授。这种疗法需要在大脑中的“内囊”部位上放置电极,再通过刺激其与前额皮质的连接来改善患者的感知及判断等认知功能。维奇表示,全球大约有200余名患者尝试过这种治疗抑郁症的方法。
同时,一些国家也尝试在吸毒者的大脑中植入电极,以此抑制患者的毒瘾。去年年底,美国的一位西佛吉尼亚州男子就在WVU Rockefeller神经科学研究所接受了这一手术,并在术后完全戒除了毒瘾。本月初,另一名吸毒患者也接受了同样的手术。
尽管现下的技术水平离广泛普及还有一段距离,但这些领域对于Neuralink而言,可谓是势在必得。在2018年一项关于脑深部刺激及其对抑郁症影响的研究综述中,科学家们表示,该项疗法的结果“有很大潜力”,但这项技术仍处于实验性阶段。“我和很多的精神病学医生聊过这个方面,他们都希望能够看到更有力的疗效数据。”维奇说道。(财富中文网)
编译:陈怡轩 冯雨涵
多数人对Neuralink这个名字并不熟悉,但这家初创公司其实也是埃隆·马斯克创立的。Neuralink的主要开发技术在于“脑机接口”,通俗而言就是将人脑与电脑连接起来进行交互。马斯克曾在推特和播客上分享过很多畅想,宣称这一技术可以缓解抑郁症、治疗强迫性神经障碍、创伤性脑损伤等等,但Neuralink一直都很神秘,鲜少出现在公众的视线当中。
正因如此,这两天出现了一个重磅消息:马斯克宣布要在当地时间8月28日下午三点(北京时间8月29日清晨6点)现场直播Neuralink脑机接口技术的“进展情况”。
马斯克在一年前曾向外界透露过Neuralink的冰山一角。2019年,Neuralink团队展示了一些搭载在细小探针上的微型电极,指出这些电极可以在损伤最小化的基础上穿透大脑组织,帮助创伤性脑损伤患者恢复大脑功能,并表示该项研究已在鼠类及灵长类动物身上完成了试验。
那么Neuralink现在的研究进展到底到了哪一步,又是否会实现马斯克的预言呢?以下是笔者就近期所有信息梳理的详细概要。
(Neuralink在)不久后就能将其技术植入人体
5月7日,马斯克在播客上作客人气节目《Joe Rogan Experience》时预测,“Neuralink在一年内就能将神经链接植入到人体内部。”不过这种植入技术并不新鲜,目前的临床医学已经可以在治疗癫痫和帕金森这类疾病的时候运用这种方法了,只是风险较高,有可能会使患者大脑出血而亡。
美国国防高级研究计划署生物技术办公室前负责人贾斯汀·桑切斯估计,全球大约有20万人的大脑中携带着某种被植入的神经技术。事实上,这种技术已经相当完备,以至于美国巴特尔纪念研究所甚至开发了一种可以帮助球手提升“挥杆速度”的神经技术设备。
另外,马斯克在当期节目中还透露,“Neuralink会在2020年进入人体实验阶段。”进行人体实验也就意味着Neuralink需要获得美国食品和药物管理局的豁免,使其免于连续性的常规监管范畴之内。这种可能性并不大,但也不是并非完全没有可能,因为大脑植入物获得豁免的情况还是存有很多先例的,只是Neuralink可能要面临更多额外的质疑和挑战。
据美国健康新闻网本周一的报道,Neuralink公司内部的关系并不和谐,该报道援引Neuralink前员工的说法,称“公司的企业文化很混乱,人才流动很快。”
(Neuralink可以)有效治疗上瘾和抑郁症状
6月10日,一位推特用户向马斯克提问,“Neuralink的技术是否可以用来抑制大脑中的上瘾症状和抑郁症状。”对此,马斯克的回答是:“当然,这项技术即伟大又可怕。”
“在大脑中放置电极可以有效缓解上瘾和抑郁。”这一点一直都是所有神经科学家所公认的。除了Neuralink,还有很多研究者也在研究这一领域,其中就包括明尼苏达大学的精神病学家和生物医学工程师埃里卡·维奇教授。这种疗法需要在大脑中的“内囊”部位上放置电极,再通过刺激其与前额皮质的连接来改善患者的感知及判断等认知功能。维奇表示,全球大约有200余名患者尝试过这种治疗抑郁症的方法。
同时,一些国家也尝试在吸毒者的大脑中植入电极,以此抑制患者的毒瘾。去年年底,美国的一位西佛吉尼亚州男子就在WVU Rockefeller神经科学研究所接受了这一手术,并在术后完全戒除了毒瘾。本月初,另一名吸毒患者也接受了同样的手术。
尽管现下的技术水平离广泛普及还有一段距离,但这些领域对于Neuralink而言,可谓是势在必得。在2018年一项关于脑深部刺激及其对抑郁症影响的研究综述中,科学家们表示,该项疗法的结果“有很大潜力”,但这项技术仍处于实验性阶段。“我和很多的精神病学医生聊过这个方面,他们都希望能够看到更有力的疗效数据。”维奇说道。(财富中文网)
编译:陈怡轩 冯雨涵
Elon Musk has made plenty of claims about Neuralink, his brain-machine interface company. On Twitter and on podcasts, the billionaire has touted abilities that sound nothing short of miraculous: easing depression, helping with obsessive compulsive disorder and treating traumatic brain injuries.
Now, Neuralink, whose work has largely been shrouded in secrecy, is set to give a public “progress update” on Friday.
In the run-up to the big reveal, Musk has allowed some glimpses at the company’s technology. An early look came a year ago, when the Neuralink team showed off tiny electrodes on thin, flexible probes they said would be able to penetrate brain tissue with minimal damage, and ultimately help restore brain function to people with traumatic brain injuries. The team has already been placing them in rats and primates.
Will the devices actually be able to achieve the breakthroughs Musk says they can? Here’s a rundown of what we know so far about Musk’s startup—the most recent claims, the technology, and what neuroscientists say is actually possible.
Claim: Neuralink will soon be able to implant its technology in humans
On May 7, Musk appeared on the popular podcast, the Joe Rogan Experience, and made a distinctive claim about Neuralink: The startup would “be able to implant a neural link in less than a year in a person, I think.” The prediction is not actually as groundbreaking as it might sound. Musk was describing a procedure that happens fairly routinely to treat conditions such as epilepsy and Parkinson’s, despite potentially fatal risks such as brain hemorrhages.
Justin Sanchez, who helped fund research done by Neuralink scientists when he ran the biological technologies office at the Defense Advanced Research Projects Agency, estimates that about 200,000 people globally have some sort of neurotechnology implanted in their brain. In fact, the technology is so well developed at this point that the Battelle Memorial Institute, where Sanchez is a fellow, has developed a neurotechnology-based non-implanted device aimed at nothing more grandiose than helping people improve their golf swings.
The other important element of Musk’s statement was that Neuralink is on track for human trials by next year. To test so quickly in humans, the company would need to get an exemption from the normal multi-year regulatory process from the Food and Drug Administration. That may be possible—other brain implants have received exemptions. But Neuralink’s device could face additional challenges.
A report in health news site Stat News this week detailed internal tensions at Neuralink, citing former employees who said the company culture could be chaotic and that it quickly cycled through scientific talent. According to two anonymous former employees, it had explored possibly by passing the U.S. regulatory process by pursuing human trials in China or Russia.
Claim: Neuralink devices will be able to treat addiction and depression
On July 10, Musk took to Twitter with another notable statement. A Twitter user asked Musk if Neuralink could be used to retrain the part of the brain that causes addiction and depression. Musk replied, “For sure. This is both great & terrifying.”
Neuroscientists agree that placing electrodes in the brain could help mitigate those conditions. In fact, researchers beyond Neuralink are working on it now, including Alik Widge, a psychiatrist and biomedical engineer at the University of Minnesota. The treatment involves applying electrodes to a spot in the brain called the internal capsule, and works by stimulating connections to the prefrontal cortex to improve cognitive functions such as perception and judgment. About 200 patients worldwide have tried the technique for depression, Widge said.
In several countries opioid addicts have had electrodes implanted into the areas of the brain that control addiction. That includes the U.S., where a West Virginia man underwent the procedure late last year at WVU Rockefeller Neuroscience Institute. He has abstained from opioids since, a spokeswoman said. A second opioid patient underwent the same surgery earlier this month.
While there are hurdles to wide adoption, there is no reason Neuralink couldn’t push into these areas in the future. In a 2018 review of studies of deep brain stimulation and its effects on depression, scientists said the results “showed promise” but the technique remained experimental. “The psychiatrists I talk with say that they want to see much stronger efficacy data,” Widge said.