在特朗普总统于沃尔特•里德医院住院期间接受的各种试验性新冠治疗药物和补充剂中,最受关注的是Regeneron公司开发的一种单克隆抗体混合药物。
该公司已公布的初步数据表明,这种通过结合实验室制造的抗体来治疗多种疾病的方法,已证明其成功阻止了无症状患者患者病情继续加重乃至住院治疗。
周三,另一家制药巨头Eli Lilly公司表示,他们在使用这种方法时也得到了类似的结果,并有足够的信心寻求食品和药物管理局(FDA)紧急使用授权(EUA)。
与Regeneron公司的声明和迄今为止的临床试验数据相类似,Eli Lilly公司的抗体混合药物能在病人接受治疗的11天内显著降低其体内的病毒载量(病毒活跃的数量),从而大幅削减医院急诊室的使用数量。该实验疗法被称为LY-CoV555和LY-CoV016,它们可以防止冠状病毒附着、感染细胞。
Lilly公司的数据看起来似乎是好消息。让人们远离医院、急诊室,正是我们的现实需求。
——Brad Loncar (@bradloncar),2020年10月7日
随着连续两种药物显示抗体混合药物疗法可能有效,其他公司或将研究同样的方法。
但是,这些疗法仅对轻度到中度的新冠患者显示出疗效(重要的是,没有严重的副作用)。已经住院的重病患者可能是另一回事。
药物的可获得性将是一个需要解决的关键细节,因为大规模生产抗体药物比制造简单的化学疗法要复杂得多。
Lilly公司此前曾表示,该公司的一种抗体疗法将在10月份生产10万剂——因为该公司在研发这种药物时就已经考虑过量产。该公司在一份电子邮件新闻稿中表示,今年晚些时候,还有数万剂的联合疗法可能面世。(财富中文网)
编译:杨二一
在特朗普总统于沃尔特•里德医院住院期间接受的各种试验性新冠治疗药物和补充剂中,最受关注的是Regeneron公司开发的一种单克隆抗体混合药物。
该公司已公布的初步数据表明,这种通过结合实验室制造的抗体来治疗多种疾病的方法,已证明其成功阻止了无症状患者患者病情继续加重乃至住院治疗。
周三,另一家制药巨头Eli Lilly公司表示,他们在使用这种方法时也得到了类似的结果,并有足够的信心寻求食品和药物管理局(FDA)紧急使用授权(EUA)。
与Regeneron公司的声明和迄今为止的临床试验数据相类似,Eli Lilly公司的抗体混合药物能在病人接受治疗的11天内显著降低其体内的病毒载量(病毒活跃的数量),从而大幅削减医院急诊室的使用数量。该实验疗法被称为LY-CoV555和LY-CoV016,它们可以防止冠状病毒附着、感染细胞。
Lilly公司的数据看起来似乎是好消息。让人们远离医院、急诊室,正是我们的现实需求。
——Brad Loncar (@bradloncar),2020年10月7日
随着连续两种药物显示抗体混合药物疗法可能有效,其他公司或将研究同样的方法。
但是,这些疗法仅对轻度到中度的新冠患者显示出疗效(重要的是,没有严重的副作用)。已经住院的重病患者可能是另一回事。
药物的可获得性将是一个需要解决的关键细节,因为大规模生产抗体药物比制造简单的化学疗法要复杂得多。
Lilly公司此前曾表示,该公司的一种抗体疗法将在10月份生产10万剂——因为该公司在研发这种药物时就已经考虑过量产。该公司在一份电子邮件新闻稿中表示,今年晚些时候,还有数万剂的联合疗法可能面世。(财富中文网)
编译:杨二一
Among the various experimental COVID-19 drugs and supplements that President Trump received during his stay at Walter Reed hospital, one of the most closely-watched is a cocktail of monoclonal antibodies being developed by Regeneron.
The company had released preliminary data suggesting that this approach, which combines lab-created antibodies in order to treat a variety of diseases, suggesting that it was successful in preventing serious hospitalization in patients who weren't too far along in showing coronavirus symptoms.
On Wednesday, another company, the drug giant Eli Lilly, said that it had seen similar results using this method and is confident enough to seek Food and Drug Administration (FDA) emergency use authorization (EUA).
Similar to Regeneron's claims and the clinical trial data it's unveiled to date, Eli Lilly's antibody cocktail was able to significantly reduce viral load (the amount of virus active) in patients who received the treatment within 11 days and significantly slashed the need for emergency room use or hospitalization. The experimental therapies are called LY-CoV555 and LY-CoV016, and they prevent the coronavirus from actually latching on to and infecting cells.
Lilly data looks like terrific news. Keeping people out of the hospital and ER is the real world benefit we are looking for. pic.twitter.com/n0BnQGUcLY
— Brad Loncar (@bradloncar) October 7, 2020
With two consecutive drugs showing that the antibody cocktail method could be significantly effective, other companies may dig into that same approach.
However, these treatments are showing efficacy (and, importantly, a lack of serious side effects) in those with mild-to-moderate COVID cases. The seriously ill who are already hospitalized could be a different story.
Availability is a key detail that needs to be worked out since mass production of an antibody drug is far more complicated than creating simpler chemical treatments.
Lilly has previously said that it will be able to produce 100,000 doses of one of its antibody therapies in October since it had already considered manufacturing while creating the drug. Tens of thousands more doses of the combination therapy could be available later this year, the company said in an emailed press release.