如果你对不含酒精的酒精类饮料不满意,你或许很快就能得到帮助。
这是《华尔街日报》最近一篇文章的观点,文中详细介绍了GABA Labs的工作。这家位于伦敦的公司正在精制一种合成醇Alcarelle,该公司称这种合成醇能够带来如同毒品一样的令人愉快的副作用,但不会有负面的影响。
伽马氨基丁酸简称GABA,是一种神经递质,可以通过阻断特定信号延缓大脑运转,从而产生镇定的效果。酒精进入大脑后,会与GABA受体结合并模仿其效果,令人放松,并产生一种温暖的感觉。GABA Labs首席科学官大卫·纳特博士对《华尔街日报》表示,它还会导致其他神经递质,产生令人不快的副作用,例如思维和活动困难等。
纳特表示,Alcarelle仅针对大脑中的GABA受体,只会释放多巴胺和5-羟色胺。它是无味的,可以添加到非酒精类饮料中,当然也可以与真正的酒精混合。
他对《华尔街日报》表示:“摄入这种合成醇的感觉与喝酒后的感觉一样。你会感到放松。你会变得侃侃而谈,更愿意社交。”
据《华尔街日报》报道,GABA Labs计划融资1,000万美元,并希望在2026年年中之前通过美国食品安全测试,之后将在欧洲市场推出产品。其他公司正在开发减少嗜酒和加快宿醉恢复速度的药物。
美国饮酒的人数似乎正在减少。据盖洛普(Gallup)统计,1977年,美国酒精消耗量达到最高峰,有71%的人表示至少偶尔会饮酒。2021年,美国的饮酒者比例只有63%。据报道,1997年以后出生的Z世代饮酒的比例低于千禧一代。密歇根大学(University of Michigan)和德克萨斯州立大学(Texas State University)2020年的报告显示,2018年,美国宣称正在戒酒的非大学生人数增长了6%,达到30%。
据美国国家酒精滥用与酒精中毒研究所(U.S. National Institute on Alcohol Abuse and Alcoholism)表示,饮酒的潜在健康负面影响包括心律不齐、心肌舒缩、中风、高血压、脂肪肝、酒精肝、肝纤维化、肝硬化、免疫系统衰弱和胰腺炎等。此外,酒精似乎可能引发各种癌症,包括头颈癌症、食道癌、肝癌、乳腺癌和结直肠癌等。(财富中文网)
翻译:刘进龙
审校:汪皓
如果你对不含酒精的酒精类饮料不满意,你或许很快就能得到帮助。
这是《华尔街日报》最近一篇文章的观点,文中详细介绍了GABA Labs的工作。这家位于伦敦的公司正在精制一种合成醇Alcarelle,该公司称这种合成醇能够带来如同毒品一样的令人愉快的副作用,但不会有负面的影响。
伽马氨基丁酸简称GABA,是一种神经递质,可以通过阻断特定信号延缓大脑运转,从而产生镇定的效果。酒精进入大脑后,会与GABA受体结合并模仿其效果,令人放松,并产生一种温暖的感觉。GABA Labs首席科学官大卫·纳特博士对《华尔街日报》表示,它还会导致其他神经递质,产生令人不快的副作用,例如思维和活动困难等。
纳特表示,Alcarelle仅针对大脑中的GABA受体,只会释放多巴胺和5-羟色胺。它是无味的,可以添加到非酒精类饮料中,当然也可以与真正的酒精混合。
他对《华尔街日报》表示:“摄入这种合成醇的感觉与喝酒后的感觉一样。你会感到放松。你会变得侃侃而谈,更愿意社交。”
据《华尔街日报》报道,GABA Labs计划融资1,000万美元,并希望在2026年年中之前通过美国食品安全测试,之后将在欧洲市场推出产品。其他公司正在开发减少嗜酒和加快宿醉恢复速度的药物。
美国饮酒的人数似乎正在减少。据盖洛普(Gallup)统计,1977年,美国酒精消耗量达到最高峰,有71%的人表示至少偶尔会饮酒。2021年,美国的饮酒者比例只有63%。据报道,1997年以后出生的Z世代饮酒的比例低于千禧一代。密歇根大学(University of Michigan)和德克萨斯州立大学(Texas State University)2020年的报告显示,2018年,美国宣称正在戒酒的非大学生人数增长了6%,达到30%。
据美国国家酒精滥用与酒精中毒研究所(U.S. National Institute on Alcohol Abuse and Alcoholism)表示,饮酒的潜在健康负面影响包括心律不齐、心肌舒缩、中风、高血压、脂肪肝、酒精肝、肝纤维化、肝硬化、免疫系统衰弱和胰腺炎等。此外,酒精似乎可能引发各种癌症,包括头颈癌症、食道癌、肝癌、乳腺癌和结直肠癌等。(财富中文网)
翻译:刘进龙
审校:汪皓
If non-alcoholic versions of alcoholic beverages just aren’t cutting it for you, help may soon be on the way.
That’s according to a recent Wall Street Journal article, which details the work of GABA Labs. The London-based company is perfecting a synthetic alcohol called Alcarelle that it claims will deliver the pleasurable side effects of the drug without the negative ones.
Gamma-aminobutyric acid, also known as GABA, is a neurotransmitter that slows the brain by blocking certain signals, thus producing a calming effect. When alcohol reaches the brain, it binds to GABA receptors and mimics its effect, relaxing people and giving them a warm feeling. But it also results in other neurotransmitters producing undesirable side effects, like difficulty thinking and moving, Dr. David Nutt, chief scientific officer at GABA Labs, told WSJ.
Alcarelle aims to target only GABA receptors in the brain, allowing for the release of dopamine and serotonin and nothing more, Nutt maintains. It’s tasteless and designed to be added to nonalcoholic drinks, though it could be mixed with real alcohol.
“It feels like what a glass of wine feels like,” he told the newspaper. “It feels relaxing. It makes you a bit more chatty, a bit more socially engaged with people.”
GABA Labs is working to raise about $10 million and aims to complete U.S. food-safety testing by mid-2026, before launching in European markets, the WSJ reports. Other companies are working to develop drugs that reduce alcohol cravings and speed recovery from hangovers.
The number of Americans who drink appears to be dropping. In the U.S., alcohol consumption peaked in 1977, when 71% said they drank at least occasionally, according to Gallup. In 2021, only 63% of Americans said they drank. Gen Z—those born from 1997 and on—is reportedly drinking less than Millennials did. And the number of Americans who aren’t in college and say they’re abstaining from alcohol rose 6% to 30% in 2018, according to a 2020 report from the University of Michigan and Texas State University.
Potential adverse health effects of drinking, according to the U.S. National Institute on Alcohol Abuse and Alcoholism, include irregular heart beat, stretching of the heart muscle, stroke, high blood pressure, fatty liver, alcoholic hepatitis, fibrosis, cirrhosis, weakening of the immune system, and pancreatitis. What’s more, alcohol appears to cause several types of cancer, including head and neck, esophageal, liver, breast, and colorectal.