新冠疫情期间,在压力和新冠后遗症的双重影响下,人们的发际线比平时更快后移。许多人在感染新冠病毒的两三个月后,脱发问题开始加重,而且这种情况会持续6至9个月。
一家硅谷生物科技初创公司dNovo开发了一种有望解决这个问题的方案。该公司称,其成功地将脂肪细胞或血细胞等普通细胞重新编程为人体毛囊。
dNovo能够用几滴血制造出可以用于生发的定制毛囊干细胞。据称,这些细胞能够逃过免疫系统攻击,避免排斥反应。
dNovo的创始人是曾经就读于斯坦福大学(Stanford University)的生物学家埃内斯托·卢扬。该公司在2019年凭借一项正在申请专利的技术首次取得突破,该技术可以利用不同人类细胞再生毛囊干细胞。这个过程分为五个步骤:采集细胞,对细胞重新编程,培养新生发细胞,将新生发细胞移植到头皮,然后等待一到三个月后长出头发。
这项技术仍然需要许多年时间才能够用于人类。目前,该技术的效果仅在老鼠身上得到了证明。
卢扬告诉《财富》杂志:“我们目前仍然在临床前开发阶段。我们展示了该技术在实验小鼠身上的效果,这让我们感到非常兴奋。”
他补充道:“我们希望最终可以在人体试验中证明该技术的效果,并将我们的产品投入商业应用,但目前还处在初级阶段。”
dNovo并非唯一一家在实验室培育生发细胞的公司。另外一家生物科技公司Stemson Therapeutics在2021年7月融资1500万美元,致力于“以新型细胞再生技术将患者人体细胞再生成毛囊”,找到解决脱发问题的办法。
2006年,日本研究人员山中伸弥发现了一种能够将任何人体组织培养成干细胞的配方。所谓的iPSC自从被发现之后,就成为许多先进疗法的基础。
Stemson Therapeutics正是采用了这个配方。该公司称它最早“利用iPSC生成新毛囊治疗脱发。”该公司的技术尚未投入商业应用。
一直以来,人们可以通过植发增加发量。但随着美国消费者改为使用人体可吸收的产品和泡沫,例如Nutrafol 和培健(Rogaine)等,进行植发的人数逐步减少。(财富中文网)
翻译:刘进龙
审校:汪皓
新冠疫情期间,在压力和新冠后遗症的双重影响下,人们的发际线比平时更快后移。许多人在感染新冠病毒的两三个月后,脱发问题开始加重,而且这种情况会持续6至9个月。
一家硅谷生物科技初创公司dNovo开发了一种有望解决这个问题的方案。该公司称,其成功地将脂肪细胞或血细胞等普通细胞重新编程为人体毛囊。
dNovo能够用几滴血制造出可以用于生发的定制毛囊干细胞。据称,这些细胞能够逃过免疫系统攻击,避免排斥反应。
dNovo的创始人是曾经就读于斯坦福大学(Stanford University)的生物学家埃内斯托·卢扬。该公司在2019年凭借一项正在申请专利的技术首次取得突破,该技术可以利用不同人类细胞再生毛囊干细胞。这个过程分为五个步骤:采集细胞,对细胞重新编程,培养新生发细胞,将新生发细胞移植到头皮,然后等待一到三个月后长出头发。
这项技术仍然需要许多年时间才能够用于人类。目前,该技术的效果仅在老鼠身上得到了证明。
卢扬告诉《财富》杂志:“我们目前仍然在临床前开发阶段。我们展示了该技术在实验小鼠身上的效果,这让我们感到非常兴奋。”
他补充道:“我们希望最终可以在人体试验中证明该技术的效果,并将我们的产品投入商业应用,但目前还处在初级阶段。”
dNovo并非唯一一家在实验室培育生发细胞的公司。另外一家生物科技公司Stemson Therapeutics在2021年7月融资1500万美元,致力于“以新型细胞再生技术将患者人体细胞再生成毛囊”,找到解决脱发问题的办法。
2006年,日本研究人员山中伸弥发现了一种能够将任何人体组织培养成干细胞的配方。所谓的iPSC自从被发现之后,就成为许多先进疗法的基础。
Stemson Therapeutics正是采用了这个配方。该公司称它最早“利用iPSC生成新毛囊治疗脱发。”该公司的技术尚未投入商业应用。
一直以来,人们可以通过植发增加发量。但随着美国消费者改为使用人体可吸收的产品和泡沫,例如Nutrafol 和培健(Rogaine)等,进行植发的人数逐步减少。(财富中文网)
翻译:刘进龙
审校:汪皓
Hairlines have receded faster than usual during the pandemic due to both stress and the aftereffects of COVID 19. After a coronavirus infection, many people experience increased hair shedding starting two to three months after becoming sick, and continuing for a total of six to nine months.
A Silicon Valley biotech startup, dNovo, has developed a possible solution for this problem. The company claims it has managed to reprogram ordinary cells, like fat or blood cells, into human hair follicles.
Starting with a few drops of blood, dNovo can produce customized hair stem cells that can be used to create new hair. The cells are said to be able to evade any immune system response that would reject them.
DNovo, founded by Stanford University–trained biologist Ernesto Lujan, had its first breakthrough in 2019 with a patent-pending technology that regenerates various kinds of human cells into hair stem cells. The process requires five steps: collecting cells, reprogramming them, growing the new hair-producing cells, adding those hair-producing cells to human scalps, and finally waiting one to three months for the hair to grow.
The technology is years away from being ready for humans. For now, its effectiveness has been shown to work only on mice.
“We are currently in the preclinical stage of development,” Lujan told Fortune. “We have shown the results in laboratory mice and are very excited with those.”
He added, “We hope to eventually demonstrate the efficacy in human trials and make our product commercially available, but at the moment we are in the early stages of the whole process.”
DNovo is not the only company working on lab-grown hair cells. Another biotech company, Stemson Therapeutics, received $15 million in funding in July to find a cure for hair loss with “with a novel cell regeneration technology using the patient’s own cells to generate new hair follicles.”
In 2006, Japanese researcher Dr. Shinya Yamanaka discovered a formula to convert any type of human tissue into stem cells. Since the discovery of so-called iPSCs, they have become the basis for many cutting-edge therapies.
Stemson Therapeutics is among them. The company claims that it is the first to “leverage an iPSC approach to treat hair loss by generating de novo hair follicles.” Its technology is not yet commercially available.
People who want more hair have long been able to get hair transplants. However, the number of such transplant procedures is declining as U.S. consumers switch to ingestible products and foams including Nutrafol and Rogaine.